Toshiyuki Takai Selected Research

Fc Receptors (Fc Receptor)

10/2014	Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis.
3/2013	Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.
1/2008	Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer.
7/2007	Pathological role of osteoclast costimulation in arthritis-induced bone loss.
12/2006	Fc receptors: their diverse functions in immunity and immune disorders.
12/2005	Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.
10/2005	[Role of Fcgamma receptors in immune regulation and diseases].
2/2005	Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer.
1/2005	Fc receptors and their role in immune regulation and autoimmunity.
4/2004	Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.

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Toshiyuki Takai Research Topics

Disease

14	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 10/2002
11	Inflammation (Inflammations) 01/2017 - 03/2003
10	Neoplasms (Cancer) 01/2022 - 09/2003
5	Rheumatoid Arthritis 01/2019 - 03/2013
5	Glomerulonephritis 01/2019 - 04/2003
4	Infections 07/2013 - 09/2007
4	Hypersensitivity (Allergy) 01/2008 - 09/2003
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2019 - 10/2012
3	Experimental Arthritis 09/2016 - 02/2002
3	Bacterial Infections (Bacterial Infection) 01/2016 - 03/2003
2	Bone Resorption 01/2019 - 03/2008
2	Immune System Diseases (Immune Disorders) 04/2015 - 12/2006
2	Lupus Nephritis 10/2014 - 04/2003
2	Osteoporosis 03/2008 - 07/2007
2	Osteopetrosis 03/2008 - 04/2004
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 07/2007 - 10/2002
2	Arthritis (Polyarthritis) 07/2007 - 04/2003
2	Septic Shock (Toxic Shock Syndrome) 08/2005 - 03/2003
1	Neoplasm Metastasis (Metastasis) 01/2022
1	Chronic Obstructive Pulmonary Disease (COPD) 08/2021
1	Emphysema 08/2021
1	Lymphoma (Lymphomas) 01/2021
1	Leukemia 01/2021
1	Pemphigus (Pemphigus Vulgaris) 01/2019
1	Osteolysis 01/2019
1	Virus Diseases (Viral Diseases) 01/2018
1	Human Influenza (Influenza) 02/2017
1	Pain (Aches) 10/2016
1	Neuralgia (Stump Neuralgia) 10/2016
1	Obesity 01/2016
1	Atherosclerosis 01/2016
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2016
1	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 03/2015
1	Nephritis 12/2014
1	Allergic Contact Dermatitis 05/2014
1	Contact Dermatitis (Eczema, Contact) 05/2014
1	Uveitis 12/2013
1	Mastocytosis 07/2013
1	Alzheimer Disease (Alzheimer's Disease) 07/2013
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 12/2012
1	Inborn Genetic Diseases (Disease, Hereditary) 08/2011
1	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 08/2011
1	Optic Nerve Injuries 04/2011
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2011
1	Traumatic Brain Injuries (Traumatic Brain Injury) 09/2010
1	Reperfusion Injury 07/2010
1	Necrosis 04/2009

Drug/Important Bio-Agent (IBA)

15	Fc Receptors (Fc Receptor)IBA 10/2014 - 02/2002
13	Immunoglobulin G (IgG)IBA 01/2019 - 03/2003
7	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 09/2010
7	AutoantibodiesIBA 01/2019 - 04/2003
7	CytokinesIBA 10/2016 - 08/2005
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2004
5	AntibodiesIBA 01/2021 - 03/2003
5	Antigen-Antibody Complex (Immune Complex)IBA 03/2015 - 04/2003
4	AntigensIBA 02/2017 - 03/2003
4	Immunoglobulin E (IgE)IBA 01/2017 - 08/2002
3	LigandsIBA 01/2021 - 07/2007
3	Biological ProductsIBA 01/2019 - 03/2009
3	DNA (Deoxyribonucleic Acid)IBA 10/2012 - 04/2003
3	IgG Receptors (Fc gamma RI)IBA 07/2007 - 01/2004
2	Angiopoietin-Like Protein 2IBA 12/2019 - 01/2016
2	Tyrosine (L-Tyrosine)FDA Link 01/2019 - 03/2008
2	Phosphotransferases (Kinase)IBA 01/2019 - 03/2008
2	HLA-G Antigens (HLA G)IBA 09/2016 - 04/2013
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2009 - 07/2007
2	NK Cell Lectin-Like Receptor Subfamily KIBA 12/2007 - 08/2006
2	LipopolysaccharidesIBA 08/2005 - 03/2003
1	MicroRNAs (MicroRNA)IBA 01/2022
1	SuspensionsIBA 08/2021
1	Pancreatic Elastase (Elastase)IBA 08/2021
1	Fibronectins (Fibronectin)IBA 01/2021
1	CTLA-4 AntigenIBA 01/2019
1	Imatinib Mesylate (Gleevec)FDA Link 01/2019
1	Abatacept (Orencia)FDA Link 01/2019
1	Tyrosine Kinase InhibitorsIBA 01/2019
1	ElementsIBA 01/2019
1	Nucleic AcidsIBA 01/2018
1	Interferon Type IIBA 01/2018
1	delta inulinIBA 02/2017
1	VaccinesIBA 02/2017
1	ChitinIBA 01/2017
1	InterleukinsIBA 04/2015
1	CollagenIBA 12/2014
1	Interleukin-1 (Interleukin 1)IBA 05/2014
1	HaptensIBA 05/2014
1	interstitial retinol-binding proteinIBA 12/2013
1	Immunoglobulin M (IgM)IBA 07/2013
1	Amyloid (Amyloid Fibrils)IBA 07/2013
1	Cytidine DeaminaseIBA 07/2013
1	DisulfidesIBA 04/2013
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2013
1	Pattern Recognition ReceptorsIBA 12/2012
1	anti-IgMIBA 08/2011
1	Small Interfering RNA (siRNA)IBA 04/2011
1	Rheumatoid FactorIBA 01/2011
1	Tec protein-tyrosine kinaseIBA 03/2008
1	NF-kappa B (NF-kB)IBA 09/2007

Therapy/Procedure

4	Therapeutics 12/2016 - 02/2005
2	Ligation 08/2005 - 09/2003